Clinical Epidemiology

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About this course: Evidence forms the basis of modern medicine. Clinical research provides us with this evidence, guiding health professionals towards solutions to problems that they face in daily practice. Transferring existing problems in medical practice to a research setting is a challenging process that requires careful consideration. The practice of clinical epidemiology aims to address this through the application of established approaches for research in human populations, while at all times focussing on the problem at hand from a clinical perspective. This course teaches the principles and practice of clinical epidemiology, drawing on real problems faced by medical professional…

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When you enroll for courses through Coursera you get to choose for a paid plan or for a free plan

  • Free plan: No certicification and/or audit only. You will have access to all course materials except graded items.
  • Paid plan: Commit to earning a Certificate—it's a trusted, shareable way to showcase your new skills.

About this course: Evidence forms the basis of modern medicine. Clinical research provides us with this evidence, guiding health professionals towards solutions to problems that they face in daily practice. Transferring existing problems in medical practice to a research setting is a challenging process that requires careful consideration. The practice of clinical epidemiology aims to address this through the application of established approaches for research in human populations, while at all times focussing on the problem at hand from a clinical perspective. This course teaches the principles and practice of clinical epidemiology, drawing on real problems faced by medical professionals and elaborating on existing examples of clinical research. Medical researchers will lean how to translate real clinical problems into tangible research questions for investigation, gaining insight into some of the most important considerations when designing an epidemiological study along the way. Core concepts will be introduced along four key themes: diagnosis, prognosis, treatment and etiology. Followers of this course will develop their understanding of the topics addressed through lectures from experts, peer interaction and review assignments.

Created by:  Utrecht University
  • Taught by:  Diederick E. Grobbee, Professor

    Clinical Epidemiology
  • Taught by:  Arno W. Hoes, Professor

    Clinical Epidemiology
Level Intermediate Commitment 7 weeks of study, 1-3 hours/week Language English How To Pass Pass all graded assignments to complete the course. User Ratings 4.7 stars Average User Rating 4.7See what learners said Trabajo del curso

Cada curso es como un libro de texto interactivo, con videos pregrabados, cuestionarios y proyectos.

Ayuda de tus compañeros

Conéctate con miles de estudiantes y debate ideas y materiales del curso, y obtén ayuda para dominar los conceptos.

Certificados

Obtén reconocimiento oficial por tu trabajo y comparte tu éxito con amigos, compañeros y empleadores.

Utrecht University Utrecht University is a research university comprising seven faculties which collectively span the entire academic spectrum in teaching and research. Founded in 1636, the University is now a modern, leading institute enjoying a growing international reputation. In the Shanghai Ranking, Utrecht University ranks 1st in the Netherlands, 17th in Europe and 56th worldwide. The research focuses on four main strategic themes: Dynamics of Youth, Institutions for Open Societies, Life Sciences and Sustainability. Our motto is: Bright minds, better future.

Syllabus


WEEK 1


About the course
Welcome! Here you will find general information about the course. The learning objectives, the structure, the format and the requirements of completion will be presented to you.


6 readings expand


  1. Leyendo: Welcome to the Course!
  2. Cuadro de aviso de la discusión: Introduce Yourself!
  3. Leyendo: Introduction
  4. Leyendo: Course Syllabus
  5. Leyendo: Book: 'Clinical Epidemiology: Principles, Methods, and Applications for Clinical Research'
  6. Leyendo: Short Survey
  7. Leyendo: Credits


WEEK 2


Introduction to Epidemiology



The course will kick off with a brief introduction to some of the key concepts in epidemiological research. We will warm up with two introductory lectures, followed by a small by assignment, before diving further into the field of epidemiology from a clinical context.


4 videos expand


  1. Video: An Introduction
  2. Video: Core Concepts
  3. Video: Defining Your Research
  4. Video: A Multi-Level Research Problem

Graded: Examples of a Clinical Problem
Graded: Introduction to Epidemiology

WEEK 3


Diagnostic Research
This week we begin at the start of the DEPTh model: Diagnosis and diagnostic research. Through a series of lectures, you will come across familiar challenges in the area of diagnosis and discover how these problems can be addressed by clinical research.


4 videos expand


  1. Video: An Introduction to Diagnostic Research
  2. Video: Core Concepts in Diagnostic Research
  3. Video: Designing a Diagnostic Study
  4. Video: Case Study: A Diagnostic Rule for Deep Vein Thrombosis in Primary Care

Graded: Example of a Diagnostic Study
Graded: Reference Standard
Graded: Diagnostic Research

WEEK 4


Prognostic Research



This week you will be introduced to the challenges of evidence-based prognostication: how can we best predict the course of a patient's health? You will learn this week how this kind of question can be addressed through epidemiological research, becoming familiar with how prognostic tools can be developed for use in guiding clinical decisions.


4 videos, 1 reading, 1 practice quiz expand


  1. Video: An Introduction to Prognostic Research
  2. Cuestionario de práctica: Examples of a Prognostic Study
  3. Video: Designing a Prognostic Study
  4. Leyendo: Feedback
  5. Video: Developing and Validating a Prediction Rule
  6. Video: Case Study: Developing a Prediction Rule for 10-year Cardiovascular Disease Risk

Graded: Study Design of Data Collection
Graded: Prognostic Research

WEEK 5


Intervention Research



In our final week of lectures, you will step into the world of intervention research, exploring the "Therapeutic" branch of the DEPTh model. We will focus on the study of intended and unintended effects, exploring a new kind of study design: the randomized controlled trial.


4 videos, 1 reading expand


  1. Video: An Introduction to Intervention Research
  2. Video: Intended Effects
  3. Video: Unintended Effects
  4. Video: Case Study: Pneumococcal Vaccination in Adults
  5. Leyendo: Preparing the Debate

Graded: Intervention Research

WEEK 6


The Online Debate
The task this week is in the form of an online debate in which you will study an existing piece of clinical research and contribute to a discussion of this research, forming both an objective assessment and using that to develop your own opinions.


2 items expand


  1. Cuadro de aviso de la discusión: Discuss the Debate

Graded: The Online Debate

WEEK 7


Exam and Conclusion
This is final assessment in the course: a quiz of 30 multiple choice questions that aim to test how well you can apply the knowledge you have gained throughout the course. Good luck!


1 reading expand


  1. Cuadro de aviso de la discusión: Farewells
  2. Leyendo: Final Survey

Graded: Clinical Epidemiology
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